Current time in Korea 09:22 Oct 24 (Tue) Year 2017 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 10
BKCSDE 22(10)
October 20, 2001 

 
Title
Inhibitory Effect of Methyl Caffeate on Fos-Jun-DNA Complex Formation and Suppression of Cancer Cell Growth
Author
Soon Pyo Lee, Gyo Jun, Eun-Jin Yoon, Seyeon Park, Chul-Hak Yang
Keywords
AP-1 binding site, Fos-Jun heterodimer, P. frutescens, Methyl caffeate, Dibutyl phthalate (DBP).
Abstract
The fos and jun proteins form a heterodimeric complex that interacts with the DNA regulatory element known as the AP-1 binding site. To search for inhibitors of the fos-jun-DNA complex formation, several natural plants extracts were screened. One of them, the methanol extract of Perilla frutescens showed inhibitory effect against the complex formation between the fos-jun dimer and the AP-1 binding site (TGAG/CTCA). Methyl caffeate and dibutyl phthalate (DBP) were isolated as the active constituents from the extract of P. frutescens by repeated column chromatography and HPLC. And their IC50 values for fos-jun-DNA complex formation were estimated as 0.29 mM and 0.55 mM, respectively. The more potent inhibitor, methyl caffeate showed cytotoxic effect against human cancer cell line (A549 and K562).
Page
1131 - 1135
Full Text
PDF