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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 3
BKCSDE 23(3)
March 20, 2002 

 
Title
Furo[3,2-h]quinoline Derivatives as a Gastric H + /K+ -ATPase Inhibitors
Author
Seung Kyu Kang, Sung Yun Cho, Sung Soo Kim, Hyae Gyeong Cheon, Joong-Kwon Choi, Eul Kgun Yum
Keywords
Furo[3,2-h]quinoline, Gastric H+/K+-ATPase inhibitors, Anti-secretory.
Abstract
Furo[3,2-h]quinoline derivatives were synthesized as a gastric H+ /K+ -ATPase inhibitors. The oxycyclization of 7 and 8-positions in quinoline potentiated the inhibitory activity, while no significant changes in biological activity were observed by the variation of substituents in furan ring. The several furo[3,2-h]quinoline derivatives were worthy of in vivo investigation for their anti-secretory and anti-ulcer activity.
Page
454 - 458
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