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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 11
BKCSDE 23(11)
November 20, 2002 

 
Title
The Crystal Structure of One Natural Compound Cyclo-(1,10-Docandiamino-11, 20-Docanedioic) Amide (1,12-Diazacyclodocosane-2,11-Dione)
Author
Wan-Xing Wei, Yuan-Jiang Pan
Keywords
1,12-Diazacyclodocosane-2,11-dione, Cyclo(1,10-docandiamino-11,20-docanedioic) amide, Crystal structure, Phyllanthus niruri Linno
Abstract
1,12-diazacyclodocosane-2,11-dione was first isolated from a plant Phyllanthus niruri Linn. Its structure has been determined by means of spectroscopy methods and X-ray crystallography. Two peptide groups in the big ring (lactam) are the main factors influencing intermolecular contacts. The hydrogen-bond interaction of these hydrophilic groups is observed in the crystal structure. Meanwhile, C-H‥O hydrogen bonds in molecules contribute to the formation of the whole crystal. These two kinds of hydrogen-bond form six- member rings among molecules. This compound crystallizes in the triclinic space group P-1 with a= 9.588(1)Å, b= 9.850(1)Å, c = 11.810(1)Å, α= 68.18(1)˚ , β= 84.98(1), γ = 86.03(1)˚ , V = 1030.66(17)Å3 , Z = 2. A disorder of five-member carbon chain in the whole ring is observed in the title compound. The bond angle 105.8(4) is determined for a extreme configuration C(14)-C(15)-C(16), and 117.7(10) for another extreme configuration C(14')-C(15')-C(16'). In this crystal, two molecules are tied each other by short intermolecular hydrogen bonds, the oxygen atom being tied by hydrogen bond to nitrogen atom of another two molecules. The NMR and IR spectral data coincides to the structure of the compound.
Page
1527 - 1530
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