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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 24, Number 10
BKCSDE 24(10)
October 20, 2003 

 
Title
A Facile One-pot Synthesis of Fused 2-Thiouracils: Dipyrimidinopyridine, Pyrazolopyrimidine and Pyridazinopyrimidines
Author
Shaker Youssif, Said El-Bahaie, Esam Nabih
Keywords
Dipyrimidinopyridine, Pyrazolo[5,4-d]pyrimidines, Pyrazolylpyrimidine, Indolodiazinopyrimidine and pyridazino[6,5-d]pyrimidine
Abstract
A novel fused thiouracil containing a heterocyclic ring system, dipyrimidinopyridine (3), has been prepared through the cyclization of compound 2. Compound 2 was formed by the formylation of 6-amino-2-thiouracil 1, pyrazolopyrimidines 8-10 via the heating of 6-arylhydrazono-2-thiouracils 5-7, compound 11, using Vilsmeier reagent with compound 4, pyrazolylpyrimidine 12, indolodiazinopyrimidine 14 and pyridazinopyrimidine 15. Pyridazino-pyrimidine 15 was formed by the condensation of compound 4 with acetylacetone, isatin and benzyl, respectively.
Page
1429 - 0
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