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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 24, Number 11
BKCSDE 24(11)
November 20, 2003 

Iron Determination in Rat Plasma Samples by Inductively Coupled Plasma Emission Spectrometry and Application to Pharmacokinetic Studies
Tiefu Li, Yingjie Deng, Guangli Ma, Jie Jin, Song Li
Inductively coupled plasma emission spectrometry, Biological fluids, Pharmacokinetic
This paper describes an inductively coupled plasa emission spectrometric method for the analysis of Fe in fat plasma. Calibration curves were obtained in the range of 0.125-1.50 ㎍·mL-1. The relative standard deviation ranges from 5.93% to 6.80% and accuracy was between 87.6 and 102.0%. Dilution with water had no influence on the performance of the method, which could then be used to quantify Fe concentration in plasma up to 0.50 ㎍·mL-1. The limit of quantification was 0.10 ㎍·mL-1. At this level, the average relative standard deviation was 6.8%. The results indicate that the method meets the accuracy and precision requirements for the pharmacokinetic studies. The Fe concentration in rat plasma was measured and the main pharmacokinetic parameters were calculated by Topfit 2.0 (GmbH. shering AG, Godecke AG, Germany).
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