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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 24, Number 11
BKCSDE 24(11)
November 20, 2003 

Integrated Microdisk Gold Electrode Modified with Metal-porphyrin and Metal-phthalocyanines for Nitric Oxide Determination in Biological Media
Il Kwang Kim, Hyun Ok Bae, Gi Soo Oh, Hun Taeg Chung, Young Jin Kim, Hyun Ja Chun
Modified electrode, NO determination, Metal-phthalocyanine, Square wave anodic stripping voltammetry
An integrated gold microdisk electrode was constructed and modified with metal-porphyrin or metalphthalocyanines for NO determination in biological media. Microanalysis of NO using square wave anodic stripping voltammetry in 1 × 10-2 M HClO4 was optimal when the accumulation potential was 0.1V, frequency 100Hz, and the scan rate was 200 mV/s. When the electrode was modified with metal-porphyrin or metalphthalocyanines, the anodic peak currents of NO increased due to the catalytic oxidation of NO. In case of Fe(II)-phthalocyanine modified electrode, the peak currents remarkably increased and the sensitivity was high. The calibration curve had good linearity in the range from 3.6 × 10-5 M to 7.2 × 10-7 M, and the detection limit was 5.7 × 10-7 M. For the structural stability and increased sensitivity, Fe(II)-phthalocyanine modified gold microdisk electrode coated with Nafion was applied to determination of NO released from cultured macrophase.
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