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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 2
BKCSDE 25(2)
February 20, 2004 

 
Title
Biological Activities of Methyl-4-[[(2E)-3,7-dimethyl-oxy]-3-hydroxybenzoate
Author
Seung Hwa Baek*, Hyun Ju Oh, Jin A Lim, Hyun Ja Chun, Hyun Ok Lee, Jong Woong Ahn, Nigel B Perry, Hyung Min Kim
Keywords
Trichocolea hatcheri, MTT assay, Antitumoral, Antimicrobial and antioxidative activities
Abstract
Methyl-4-[[(2E)-3,7-dimethyl-2,6-octadienyl]oxy]-3-hydroxybenzoate (5) has been identified from the New Zealand liverwort Trichocolea hatcheri (T. hatcheri) on the basis of spectroscopic evidence. This compound was tested for its growth inhibitory effects against tumor cell lines, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. It showed growth inhibition activity against Staphylococcus epidermidis (MIC, 1,000 μg/mL). These results suggest that compound 5 possesses antitumoral , antimicrobial and antioxidative activities.
Page
195 - 197
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