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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 2
BKCSDE 25(2)
February 20, 2004 

 
Title
Oxidative N-Debenzylation of N-Benzyl-N-substituted Benzylamines Catalyzed by Cytochrome P450
Author
Sung Soo Kim*, Gang Lin, Ji Won Yang
Keywords
Oxidations, N-Debenzylations, Horseradish peroxidase, Hydrogen peroxide, Amines
Abstract
Cytochrome P450 (P450)/O2/NADPH engender electron transfer reaction of N-benzyl-N-substituted benzylamines to yield corresponding radical cation 1 that is simultaneously converted into 2 and 3. Subsequently, expulsion of proton and hydroxylation yielding a-hydroxylamines are followed by formation of benzaldehydes and benzylamines.
Page
249 - 252
Full Text
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