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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 12
BKCSDE 25(12)
December 20, 2004 

 
Title
Correlation Equation for Retention Factor and Resolution of Ibuprofen in SFC
Author
Soon Koo Han, Yinzhe Jin, Kyung Ho Row*
Keywords
SFC, Retention factor, Resolution, Ibuprofen, Correlation
Abstract
Supercritical fluid chromatography (SFC) was considered for separating racemic ibuprofen. The chromatographic column (3.9 × 150 mm) was packed with Kromasil? CHI-TBB, and the mobile phase was supercritical carbon dioxide with modifier of IPA. The experimental variables were the content of IPA, and temperature and pressure of supercritical mobile phase. To determine the separation condition, the empirical equation of retention factor and resolution was proposed. In the case of retention factor, the empirical equation was in the form, k = a ρ + b/F + c ( ρ/F) + d. The empirical equation for resolution was proposed as a linear form, R = a ρ + b F + c.
Page
1807 - 1811
Full Text
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