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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 1
BKCSDE 27(1)
January 20, 2006 

Understanding the RNA-Specificity of HCV RdRp: Implications for Anti-HCV Drug Discovery
Jinyoung Kim, Youhoon Chong*
HCV RNA-dependent RNA polymerase (RdRp), Nucleoside inhibitors, Molecular modeling, Drug design
Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.
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