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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 5
BKCSDE 27(5)
May 20, 2006 

Carnosine and Related Compounds Protect against the Hydrogen Peroxide-Mediated Cytochrome c Modification
Jung Hoon Kang
Cytochrome c, Oligomerization, Free radical scavenger, Carnosine
Carnosine, homocarnosine and anserine might act as anti-oxidants and free radical scavengers in vivo. In the present study, the protective effects of carnosine and related compounds on the H2O2-mediated cytochrome c modification were studied. Carnosine, homocarnosine and anserine significantly inhibited the oligomerization of cytchrome c induced by H2O2. All three compounds also inhibited the formation of carbonyl compound and dityrosine during the incubation of cytochrome c with H2O2. These compounds effectively inhibited the peroxidase activity in the cytchrome c treated with H2O2. The results suggested that carnosine, homocarnosine, and anserine might protect cytochrome c against H2O2-mediated oxidative damage through a free radical scavenging.
663 - 666
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