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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 5
BKCSDE 27(5)
May 20, 2006 

 
Title
Selection and Analysis of Genomic Sequence-Derived RNA Motifs Binding to C5 Protein
Author
Kwang-sun Kim, Hyejin Ryoo, June Hyung Lee, Meehyun Kim, Taeyeon Kim, Yool Kim, Kook Han, Seol-Hoon Lee, Younghoon Lee*
Keywords
C5 protein, Genomic SELEX, Aptamer, RNA-protein interaction, M1 RNA
Abstract
Escherichia coli RNase P is a ribonucleoprotein composed of M1 RNA and C5 protein. Previously, analysis of RNA aptamers selected for C5 protein from a synthetic RNA library showed that C5 protein could bind various RNA molecules as an RNA binding protein. In this study, we searched cellular RNA motifs that could be recognized by C5 protein by a genomic SELEX approach. We found various C5 protein-binding RNA motifs derived from E. coli genomic sequences. Our results suggest that C5 protein interacts with various cellular RNA species in addition to M1 RNA.
Page
699 - 704
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