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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 6
BKCSDE 27(6)
June 20, 2006 

 
Title
Lipid Peroxidation Induced by the Reaction of Cytochrome c with Hydrogen Peroxide
Author
Jung Hoon Kang
Keywords
Cytochrome c, Lipid peroxidation, Free radical, Carnosine
Abstract
Lipid peroxidation induced by the reaction of cytochrome c with H2O2 was investigated. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with cytochrome c and H2O2, lipid peroxidation was increased in cytochrome c and H2O2 concentrations-dependent manner. Radical scavengers, azide, formate and ethanol prevented lipid peroxidation induced by the cytochrome c/H2O2 system. Iron specific chelator, desferoxamine also prevented the cytochrome c/H2O2 system-mediated lipid peroxidation. These results suggest that lipid peroxidation may be induced by the cytochrome c/H2O2 system via the generation of free radicals. Carnosine, homocarnosine and anserine are present in the muscle and brain of many animals and human. Previous studies show that these compounds have an antioxidant function. In the present study, carnosine, homocarnosine and anserine significantly prevented the cytochrome c/H2O2 system-mediated lipid peroxidation. Carnosine and related compounds also inhibited the free radical-generating activity of cytochrome c. The results suggest that carnosine, homocarnosine and anserine may prevent lipid peroxidation induced by the cytochrome c/H2O2 system through a free radical scavenging.
Page
830 - 0
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