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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 6
BKCSDE 27(6)
June 20, 2006 

 
Title
Asymmetric Michael Reaction of Malonate Derivatives with α,β-Unsaturated Ketones Using Chiral Quaternary Ammonium Salts
Author
Min Je Cho, Myoung Gi Cho, Sun Chul Huh, Sung Min Kim, Kilsung Lee, Kwang Oh Koh, Joo Yang Mang, Dae Young Kim*
Keywords
Phase-transfer catalyst, Michael reactions, Asymmetric reactions, Malonates, Fluoromalonates
Abstract
The catalytic enantioselective Michael reaction promoted by quaternary ammonium salts from Cinchona alkaloids as a phase-transfer catalyst is described. Treatment of malonates with α,β-unsaturated ketones under mild reaction conditions afforded the corresponding Michael adducts in good yields with good to moderate enantiomeric excesses.
Page
857 - 0
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