Current time in Korea 02:32 Oct 22 (Sun) Year 2017 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 8
BKCSDE 27(8)
August 20, 2006 

Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II
Jin-Woong Kim, Hyeong Beom Park, Bong Young Chung, Jong Baek Lee, Jung-Hyuck Cho, Chang-Hyun Oh*
1β-Methylcarbapenem, Antibacterial activity, DHP-I stability
The synthesis of a new series of 1β-methylcarbapenems having 5-(α,β-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having α-hydroxy-β-piperazinylethyl substituted moiety showed the most potent activity.
1164 - 1170
Full Text