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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 10
BKCSDE 27(10)
October 20, 2006 

 
Title
Asymmetric Cyanosilylation of Aldehydes by Chiral Ti-TADDOL Complex
Author
Sung Soo Kim*, Ju Myung Kwak, Gurusamy Rajagopal
Keywords
Cyanosilylation, Aldehyde, Ti-TADDOL, Double activation
Abstract
A variety of chiral cyanohydrins were readily prepared from aldehydes with TMSCN under the influence of chiral titanium complex formed in situ from Ti(OiPr)4/TADDOL(I) in the presence of Ph3PO as additive. The double activation method produces trimethylsilylethers in excellent yield (95%) with moderate enantiomeric excess.
Page
1638 - 1640
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