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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 5
BKCSDE 28(5)
May 20, 2007 

 
Title
Novel Synthesis of the Natural Protoberberine Alkaloids: Oxypalmatine and Oxypseudopalmatine
Author
Thanh Nguyen Le, Won-Jea Cho*
Keywords
Oxypalmatine, Oxypseudopalmatine, 3-Arylisoquinolinones
Abstract
Oxypalmatine and oxypseudopalmatine were synthesized in three steps from the benzonitrile 11 and toluamides 12a, b. The lithiated cycloaddition reaction yielded 3-arylisoquinolinone intermediates. A subsequent internal SN2 reaction produced the corresponding 8-oxoprotoberberines, oxypalmatine and oxypseudopalmatine.
Page
763 - 766
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