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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 6
BKCSDE 28(6)
June 20, 2007 

Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects
Long-Xuan Zhao, Hyeung-geun Park, Sang-sup Jew, Mi Kyeong Lee, Young Choong Kim, Pritam Thapa, Radha Karki, Yurngdong Jahng, Byeong-Seon Jeong, Eung-Seok Lee*
Asiatic acid, Hepatoprotective effect, Structural modification, Hepatotoxicity
For the development of novel hepatoprotective agents, C11, C28, C2,3,23 or C2,23,28 functional groups on asiatic acid were modified, and their hepatoprotective effects were evaluated. Most of the prepared compounds displayed potent hepatoprotective activities against CCl4- and galactosamine (GaIN)-induced hepatotoxicity. Especially, compounds 16 and 20 showed the most significant hepatoprotective effects against GaIN-induced hepatotoxicity (54.2% and 46.4% protection at 50 mM, respectively).
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