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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 11
BKCSDE 28(11)
November 20, 2007 

 
Title
Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Author
Valentina A. Ol'shevskaya, Andrey V. Zaytsev, Arina N. Savchenko, Alexander A. Shtil, Chan Seong Cheong, Valery N. Kalinin*
Keywords
Carboranes, Porphyrins, Drug resistance, Photodynamic therapy, Boron neutron capture therapy
Abstract
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
Page
1910 - 1916
Full Text
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