Current time in Korea 11:52 Oct 22 (Sun) Year 2017 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 10
BKCSDE 29(10)
October 20, 2008 

Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents
Kyung Ran Kim, Ah Young Park, Hyung Rock Lee, Jin Ah Kang, Won Hee Kim, Pusoon Chun, Jang Ho Bae, Lak Shin Jeong, Hyung Ryong Moon*
Bicyclo[3.1.0]hexanone, Intramolecular carbenoid cycloaddition, Mitsunobu reaction, Diastereoselective reduction, North conformation
Novel bicyclo[3.1.0]hexanyl purine nucleoside analogues were synthesized as potential antiherpetic agents via a bicyclo[3.1.0]hexanol (±)-8, which was prepared using a highly efficient carbenoid cycloaddition reaction. A highly diastereoselective reduction of ketone and a Mitsunobu reaction for the condensation of glycosyl donor (±)-12 with 6-chloropurine were employed.
1977 - 1982
Full Text