Current time in Korea 20:52 Sep 22 (Fri) Year 2017 KCS KCS Publications
KCS Publications
My Journal Log In Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 10
BKCSDE 29(10)
October 20, 2008 

Synthesis and Biological Properties of Luotonin A Derivatives
A F M Motiur Rahman, Dong Hyeon Kim, Jing Lu Liang, Eung Seok Lee, Younghwa Na, Kyu Yeon Jun, Youngjoo Kwon, Yurngdong Jahng
Luotonin A, Topoisomerase I, Topoisomerase II, Cytotoxicity, Friedlander reaction
A series of new derivatives on the ring A of luotonin A were prepared by Friedlander condensation of 6,7,8,10- tetrahydropyrrolo[2,1-b]quinazoline-6,10-dione and suitably substituted 2-aminobenzaldehydes and 2- aminoacetophenones. Their inhibitory activities on topoisomerases and cytotoxicities against selected human cancer cell lines were evaluated. Among the compounds tested, 8-fluoroluotonin A showed similar inhibitory activity on topoisomerase I comparable to camptothecin while luotonin A and 9-hydroxyluotonin A showed 1.37 and 0.94 times stronger inhibitory activity, respectively, on topoisomerase II compared to etoposide. Some derivatives of luotonin A showed moderate cytotoxicity. The possible relationship between the inhibitory activity on Topo II and the cytotoxicity of luotonin A and its analogues, thus, cannot be ruled out.
1988 - 1992
Full Text