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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 10
BKCSDE 29(10)
October 20, 2008 

 
Title
Preparation and Characterization of Vesicles Using Octasubstituted Cyclotetraphosphazene
Author
Young Jae Shin, Chul Soon Park, Chun Il Lee, Jae Sup Shin*
Keywords
Cyclotetraphosphazene, Vesicle, Cholesterol, Encapsulation efficiency
Abstract
A cyclotetraphosphazene derivative with eight chains was synthesized from octachlorocyclotetraphosphazene. The vesicles were prepared using the cyclotetraphosphazene derivative and cholesterol. The resulting vesicles were characterized by TEM and measurements of their encapsulation efficiency. The stability of the vesicles was enhanced with the addition of dihexadecylphosphate. The size and the encapsulation efficiency of the vesicles changed according to the amount of cholesterol added. The size and the encapsulation efficiency of the vesicle were lowest when the mole ratio (cholesterol: the cyclophosphazene derivative) was 0.9.
Page
2005 - 2008
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