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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 11
BKCSDE 29(11)
November 20, 2008 

 
Title
SAR Study of β-Aminoacyl-Containing Cyclic Hydrazide Derivatives
as DPP-IV Inhibitors
Author
Mi Ae Jun, Mi Sik Shin, Woul Seong Park, Seung Kyu Kang, Ki Young Kim, Sang Dal Rhee, Duck Hyung Lee, Hyae Gyeong Cheon, Jin Hee Ahn*, Sung Soo Kim*
Keywords
Dipeptidyl peptidase IV, Diabetes, Cyclic hydrazide
Abstract
In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β- aminoacyl-containing 5-, 6- and 7- membered cyclic hydrazide derivatives was synthesized. All the compounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit on basic skeleton is identified to show good in vitro activity.
Page
2129 - 0
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