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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 11
BKCSDE 29(11)
November 20, 2008 

Preparation and Application of a New Liquid Chromatographic Chiral Stationary Phase Based on Cefaclor
Hwan Sun Cho, Hyun Ju Ha, Hee Jung Choi, Jong Sung Jin*, Myung Ho Hyun*
Cefaclor, Chiral stationary phase, N-(3,5-Dinitrobenzoyl)-α-amino acids, O-Ethoxycarbonyl-2-
hydroxycarboxylic acids, 3-Substituted 1,4-benzodiazepine-2-ones
A new HPLC chiral stationary phase (CSP) was prepared by bonding N-(3,5-dinitrobenzoyl)cefaclor to silica gel. The effective π-π donor-acceptor interaction between the CSP and analytes was demonstrated to be important for the chiral recognition by applying the new CSP to the resolution of N-(substituted benzoyl)leucine ethyl esters and N-(substituted benzoyl)leucine propyl amides. The new CSP was also successfully applied to the resolution of anilide derivatives of N-acetyl-α-amino acids, anilide derivatives of Oethoxycarbonyl- 2-hydroxycarboxylic acids and 3-substituted 1,4-benzodiazepin-2-ones.
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