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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 2
BKCSDE 30(2)
February 20, 2009 

 
Title
Effect of Hydrogenated Lecithin on Cytotoxicity of Liposome
Author
Duck Hwan Bae, Jae Sup Shin, Fan Long Jin, Gwi Su Shin, Soo Jin Park*
Keywords
Lecithin, Liposome, Particle size, Turbidity, Cytotoxicity
Abstract
In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (Tc) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above Tc was smaller than that prepared below Tc. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC50 value, which shows its high safety in this study.
Page
339 - 342
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