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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 2
BKCSDE 30(2)
February 20, 2009 

 
Title
MWCNT/Fibrin Bionanocomposites by in situ Enzymatic Polymerization
Author
Mijin Kim, Jun Ho Jang, Jung Hun Han, Yong Won Lee, Sang min Cho, Sung Yong Son, John Hulme, Insung S Choi*, Hyun jong Paik*, Seong Soo A An*
Keywords
Bionanocomposites, Multiwalled carbon nanotube, Transglutaminase-catalyzed polymerization, Fibrinogen, Fibrin
Abstract
In this work multiwalled carbon nanotube (MWCNT)/fibrin hybrid structures were synthesized via the transglutaminase- catalyzed polymerization of fibrinogen (FBG). Specifically, FBG was tethered onto oxidized MWCNTs by amide coupling, and the in situ polymerization of FBG to fibrin was performed by plasma transglutaminase (Factor XIIIa) in the presence of thrombin. The attached FBG was found to be biologically active and was polymerized to fibrin by thrombin and Factor XIIIa. MWCNT-FBG and MWCNT-Fibrin structures were characterized by FT-IR spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) spectroscopy.
Page
405 - 408
Full Text
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