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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 5
BKCSDE 30(5)
May 20, 2009 

 
Title
A Novel Deposition Method of PLGA Nanoparticles on Coronary Stents
Author
Jae ryang Joo, Hye Yeong Nam, So Hee Nam, Insu Baek, Jong Sang Park*
Keywords
PLGA, Paclitaxel, Stent, Nanoparticle deposition
Abstract
Bare metal stents which were used to treat coronary artery disease have several biochemical problems. Polymerbased drug-eluting stents (DES) have opened up a new paradigm in the treatment of in-stent restenosis. Many studies and research programmes have proved that DES can prevent restenosis. In our study, paclitaxel-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles have been deposited along the three dimensional scaffold of coronary stents by a method using self-assembling properties of colloidal particles. We found that the nanoparticles were deposited uniformly and closely packed. The amount of paclitaxel was easily controlled by the drug content of the nanoparticles and the deposition count.
Page
1085 - 1087
Full Text
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