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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 9
BKCSDE 30(9)
September 20, 2009 

Application of Cl3CCONH2/PPh3 towards the Synthesis of Bioactive Amides
Skydow Chaysripongkul, Wanchai Pluempanupat, Doo Ok Jang*, Warinthorn Chavasiri*
Trichloroacetamide, Triphenylphosphine, Chlorinating agent, Amide
Cl3CCONH2 coupled with PPh3 was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.
2066 - 2070
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