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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 10
BKCSDE 30(10)
October 20, 2009 

 
Title
Polymorphic Forms of Furosemide Characterized by THz Time Domain Spectroscopy
Author
Min Ge, Guifeng Liu*, Shihua Ma, Wenfeng Wang*
Keywords
Terahertz, Furosemide, DFT, XRPD, Polymorphic forms
Abstract
Terahertz time domain spectroscopy (THz-TDS) is applied in transmission to identify the five forms of modifications of furosemide and one commercial product from 0.3 THz to 1.6 THz at room temperature. The different absorption spectra of the different forms are sensitive to crystal structures. Density function theory (DFT) calculation was used to understand the vibrational modes of furosemide in the THz region. X-ray powder diffractometry (XRPD) was applied to confirm the different forms of modifications. The results demonstrate that THz-TDS is a potential analytical technique in investigating polymorphic forms in the pharmaceutical fields.
Page
2265 - 2268
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