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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 1
BKCSDE 31(1)
January 20, 2010 

Quinolone Alkaloids from Evodiae fructus Inhibit LFA-1/ICAM-1-mediated Cell Adhesion
Seung Woong Lee, Jong Sun Chang, Ju Hwan Lim, Min Seok Kim, Su Jin Park, Hyung Jae Jeong, Min Soo Kim, Woo Song Lee*, Mun Chual Rho*
Evodiae fructus, Rutaceae, Quinolone alkaloid, Cell adhesion molecules, THP-1 cells
Four quinolone alkaloids were isolated by bioactivity-guided fractionation from the methanol extracts of Evodiae fructus fruits. Structures of compounds were elucidated by spectroscopic analysis (1H-, 13C-NMR and MS), as follows: 1-methyl-2-undecyl-4(1H)-quinolone (1), evocarpine (2), dihydroevocarpine (3) and mixture of [1-methyl-2-[(Z)-10- pentadecenyl]-4(1H)-quinolone and 1-methyl-2-[(Z)-6-pentadecenyl]-4(1H)-quinolone] (4). They inhibited the interaction of sICAM-1 and LFA-1 in THP-1 cells at IC50 values of >150 (1), 109.8 (2), >150 (3) and 40.9 μM (4), respectively,
64 - 68
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