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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 2
BKCSDE 31(2)
February 20, 2010 

Combining Information of Common Metabolites Reveals Global Differences between Colorectal Cancerous and Normal Tissues
Young Kee Chae*, Woo Young Kang, Seong Hwan Kim, Jong Eun Joo, Joon Kil Han, Boo Whan Hong
NMR, Metabolomics, Profiling, Colorectal cancer, PCA
Metabolites of colorectal cancer tissues from 12 patients were analyzed and compared with those of the normal tissues by two-dimensional NMR spectroscopy. NMR data were analyzed with the help of the metabolome database and the statistics software. Cancerous tissues showed significantly altered metabolic profiles as compared to the normal tissues. Among such metabolites, the concentrations of taurine, glutamate, choline were notably increased in the cancerous tissues of most patients, and those of glucose, malate, and glycerol were decreased. Changes in individual metabolites varied significantly from patient to patient, but the combination of such changes could be used to distinguish cancerous tissues from normal ones, which could be done by PCA analysis. The traditional chemometric analysis was also performed using AMIX software. By comparing those two results, the analysis via 1H-13C HSQC spectra proved to be more robust and effective in assessing and classifying global metabolic profiles of the colorectal tissues.
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