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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 3
BKCSDE 31(3)
March 20, 2010 

Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
Yasuaki Kimura, Kenzo Yamatsugu, Motomu Kanai*, Noriko Echigo, Takashi Kuzuhara, Masakatsu Shibasaki*
Tamiflu, Immobilization, Affinity chromatography, Abnormal behavior, Neuraminidase
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.
588 - 594
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