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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 3
BKCSDE 31(3)
March 20, 2010 

Separation of the Enantiomers of β-Blockers Using Brush Type Chiral Stationary Phase Derived from Conformationally Rigid α-Amino β-Lactam
William H Pirkle, Wonjae Lee*
Enantiomer separation, β-Blockers, Chiral stationary phase
A brush type chiral stationary phase (CSP 2) derived from α-amino β-lactam was prepared for the separation of the enantiomers of β-blockers. Compared to the CSP derived from α-amino phosphonate (CSP 1), in general, the conformationally rigid CSP 2 showed greater scope and much enhanced enantioselectivity for the resolution of β-blockers. The effect of various salt additives on enantioseparation of β-blockers in the mobile phase was investigated. The unusual effect of temperature on the chromatographic behaviors was observed on CSP 2. It also afforded appreciable increases in enantioselectivity without significantly affecting resolution, as the column temperature was reduced.
620 - 623
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