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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 6
BKCSDE 31(6)
June 20, 2010 

 
Title
Spectrophotometric Determination of Allopurinol Drug in Tablets: Spectroscopic Characterization of the Solid CT Complexes
Author
Moamen S Refat*, Gehad G Mohamed, Ahmed Fathi
Keywords
Allopurinol, DDQ, p-CLA, Spectrophotometry, Charge transfer complexes
Abstract
Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy- p-benzoquinone (p-CLA) for estimation of ALP drug (act as e-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming from different companies. Elucidation of the chemical structure of the solid CT complexes formed via reaction between drugs under study and π-acceptors, using elemental analyses (C, H, N), I. R., 1H NMR and mass spectrometry.
Page
1535 - 1542
Full Text
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