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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 7
BKCSDE 31(7)
July 20, 2010 

 
Title
Synthesis, Molecular and Microstructural Study of Poly-N-Vinylpyrrolidone
Oximo-L-Valyl-Siliconate with IR, 1H-NMR and SEM
Author
Man Singh*, G Vani Padmaja*
Keywords
Poly-N-vinyl pyrrolidone oxime, Orthosilicic acid, TEOS, Poly-N-vinyl pyrrolidone oximo-Lvalyl siliconate, SEM
Abstract
By reducing PVP with H2NOH.HCl and NaOH 2:2:1 mass ratios in aqueous ethanol, poly-N-vinyl pyrrolidone oxime [PVPO] was prepared with 92% yield. Applying the sol-gel concept, orthosilicic acid [OSA] was made by hydrolyzing TEOS with ethanol in 1:0.5 molar ratios using 1 N KOH aqueous solution as a catalyst. The OSA + PVPO + L-Valine (α-amino acid) were mixed with pure ethanolic medium in 1:2:2 mass ratios and refluxed at 78 oC and 6 pH for 6.5 h. A white residue of poly-N-vinyl pyrrolidone oximo-L-valyl-siliconate [POVS] appeared after 5 h. The heating of reaction mixture was stopped and the contents were brought to NTP. The residue formation of POVS was intensified with lowering a temperature and completely solidified within 5 h, was filtered using a vacuum pump with Whatmann filter paper no. 42. The residue of POVS was washed several times with 20% aqueous cold ethanolic solution and dried in vacuum chamber at 25 oC for 24 h. The MP was noted above 350 oC. Structural and internal morphology were analyzed with IR and 1H-NMR, and SEM respectively. A drug loading and transporting ability of the POVS in water and at pH = 5 and 8 was determined chromatographically.
Page
1869 - 1874
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