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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 9
BKCSDE 31(9)
September 20, 2010 

 
Title
Design and Synthesis of Metallopeptide Sensors: Tuning Selectivity with Ligand Variation
Author
Joung Min Kim, Bishnu Prasad Joshi, Keun Hyeung Lee*
Keywords
Peptides, Zn2+, Cd2+, Peptide sensor, Chemical sensor
Abstract
We chose a fluorescent pentapeptide sensor (-CPGHE) containing a dansyl fluorophore as a model peptide and investigated whether the selectivity and sensitivity of the peptides for heavy and transition metal ions could be tuned by changing amino acid sequence. In this process, we developed a selective peptide sensor, Cp1-d (-HHPGE, Kd = 670 nM) for detection of Zn2+ in 100% aqueous solution and a selective and sensitive peptide sensor, Cp1-e (-CCHPGE, Kd = 24 nM) for detection of Cd2+ in 100% aqueous solution. Overall results indicate that the selectivity and sensitivity of the metallopeptide sensors to specific heavy and transition metal ions can be tuned by changing amino acid sequence.
Page
2537 - 2541
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