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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 9
BKCSDE 31(9)
September 20, 2010 

 
Title
Spectrofluorimetric Determination of Bisphosphonates in Biological Sample
with a Fluorescent Chemosensor, NadDPA-2Zn2+
Author
Yunseong Jeong, Soon Young Kim, Geun woo Jin, Songhie An, Jae Han Lee, A reum Jeong, Yeonsoon Chio, Jong In Hong*, Jong Sang Park*
Keywords
Chemosensor, Fluorescent chemosensor, Bisphosphonate, Alendronate, Risedronate
Abstract
The accurate determination of bisphosphonate levels in bone and biological fluids is important in both clinical and pharmacological/toxicological studies; however, the quantitative analysis of the bisphosphonate is difficult because its concentration is quite low in most of biological sample. A novel fluorescent chemosensor (FCS)-based measurement method of bisphosphaonate levels using Naphta-diDPA-2Zn2+ (NadDPA-2Zn2+, DPA = dipycolylamine), an excellent FCS previously used for detecting PPi, was developed. By the FCS method, the concentration of bisphosphonates having no fluorophores can be determined analyzed with sufficient sensitivity. The results of this study indicate that the FCS-based measurement can be a useful method to analyze bisphosphonates in biological samples.
Page
2561 - 2564
Full Text
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