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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 10
BKCSDE 31(10)
October 20, 2010 

 
Title
Wet SiO2 As a Suitable Media for Fast and Efficient Reduction of Carbonyl Compounds with NaBH3CN under Solvent-Free and Acid-Free Conditions
Author
Mehri Kouhkan, Behzad Zeynizadeh*
Keywords
NaBH3CN, Wet SiO2, Solvent-free, Microwave irradiation, Reduction
Abstract
Reduction of carbonyl compounds such as aldehydes, ketones, α,β-unsaturated enals and enones, α-diketones and acyloins was carried out readily with NaBH3CN in the presence of wet SiO2 as a neutral media. The reactions were performed at solvent-free conditions in oil bath (70 - 80 oC) or under microwave irradiation (240 W) to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.
Page
2961 - 2966
Full Text
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