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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 11
BKCSDE 31(11)
November 20, 2010 

 
Title
Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression
Author
Byung Seok Moon, Nam Hyun Jo, Kyo Chul Lee, Mohammed I El Gamal, Gwang Il An, Su Hee Hong, Tae Hyun Choi, Won Kyoung Choi, Jin Hun Park, Jung Hyuck Cho, Gi Jeong Cheon*, Chang Hyun Oh*
Keywords
HSV1-TK, D-[18F]FMAU, L-[18F]FMAU, PET imaging, MicroPET
Abstract
D-[18F]FMAU and L-[18F]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[18F]FMAU and L-[18F]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[18F]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[18F]FMAU. On the other hand, L-[18F]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[18F]FMAU. L-[18F]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.
Page
3309 - 3312
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