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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 12
BKCSDE 31(12)
December 20, 2010 

 
Title
Silica Supported Tungstosilicic Acid as an Efficient and Reusable Catalyst for the One-Pot Synthesis of β-Acetamido Ketones via a Four-Component Condensation Reaction
Author
Masoud Nasr Esfahani*, Morteza Montazerozohori, Tahere Gholampour
Keywords
β-Acetamido ketone, Silica supported tungstosilicic acid, Four-component, Dakin-West reaction
Abstract
Silica supported tungstosilicic acid has been used as an effective catalyst for a modified Dakin-West one-pot, fourcomponent condensation of an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile for the synthesis of β-acetamido ketones. This catalytic system can act as an active, inexpensive, recoverable and recyclable catalyst. Some advantages of this system are short reaction times, good to excellent yields, easy work up and the ability to be carried out at the large scale reactions.
Page
3653 - 3657
Full Text
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