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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 4
BKCSDE 32(4)
April 20, 2011 

 
Title
Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line
Author
Hyemi Ahn, Jun A Lee, Hwan Kim, Chang Hyun Oh, So Ha Lee, Taebo Sim, Jung Mi Hah, Dong Jin Kim, Kyung Ho Yoo*
Keywords
Pyridinylcarbonylpyrimidines, Antiproliferative activity, Melanoma cell line
Abstract
The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC50 = 5.5 μM) as a reference compound. In our series, urea compound 1o having 4-chloro-3- trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC50 value of 1.4 μM.
Page
1209 - 1214
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