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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 4
BKCSDE 32(4)
April 20, 2011 

 
Title
Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
Author
Jungkyun Im, Kaustabh K. Maiti, Wanil Kim, Kyong Tai Kim, Sung Kee Chung *
Keywords
Quantum dot, Molecular transporter, Internalization, Macropinocytosis, Blood-brain barrier
Abstract
The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.
Page
1282 - 1292
Full Text
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