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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 6
BKCSDE 32(6)
June 20, 2011 

 
Title
Inhibition of Invasion and Capillary-like Tube Formation by Retrohydroxamate-based MMP Inhibitors
Author
Seung-Su Choi, Ae-Ri Ji, Seung-Woo Yu, Bong-Hwan Cho, Jung Dae Park, Jun Hyoung Park, Hyun Soo Lee, Seong Eon Ryu, Dong Han Kim, Jae-Hoon Kang, Seung-Taek Lee*
Keywords
Inhibitor, Invasion, Matrix metalloproteinase (MMP), N-Formylhydroxylamine, Retrohydroxamate
Abstract
Matrix metalloproteinases (MMPs), a family of zinc-containing endopeptidases, participate in many normal processes such as embryonic development and wound repair, and in many pathological situations such as cancer, atherosclerosis, and arthritis. Peptidomimetic MMP inhibitors were designed and synthesized with Nformylhydroxylamine (retrohydroxamate) as a zinc-binding group and various side chains on the α, P1', and P2' positions. Using in vitro MMP assays with purified MMPs (MMP-1, MMP-2, MMP-3, MMP-9, and MMP- 14) and fluorogenic peptide substrates, it was found that compounds 2d and 2g selectively inhibit gelatinases (MMP-2 and MMP-9) and interstitial collagenase (MMP-1). They also inhibited the chemo-invasion of fibrosarcoma HT-1080 cells and tube formation of human umbilical vascular endothelial cells in a dosedependent manner. Our results suggest that retrohydroxamate-based MMP inhibitors, especially compounds 2d and 2g, have the potential to be used as therapeutic drugs for cancer and other MMP-related diseases.
Page
2032 - 2038
Full Text
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