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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 8
BKCSDE 32(8)
August 20, 2011 

 
Title
Synthesis of Halicylindramide A Mimetics Containing Lactone Isosteres
Author
Sanghyuk Yeo, Hyunju Seo, Dongyeol Lim *
Keywords
Synthesis, Halicylindramide A, Mimetic, Depsipeptide
Abstract
Synthesis of halicylindramide A mimetics via solid-phase peptide synthesis is described. The N-Me-Gly-Thr residues in halicyclindramide A has been replaced by N-Me-Gly-Dpr, Lys, or N-Me-Gly-allo-Thr. Solution structures of the mimetics were compared by CD spectroscopy in an aqueous buffer and in TFE.
Page
2916 - 2920
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