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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 11
BKCSDE 32(11)
November 20, 2011 

 
Title
Efficient Ultrasound Enhance Novel Series of 2-((E)-2,3-Dihydro-2-(4- (phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol as an Antimicrobial Agent
Author
Asha V. Chate, Ratnadeep S. Joshi, Pravin V. Badadhe, Sanjay K. Dabhade, Charansingh H. Gill *
Keywords
1,5-Benzothiazepines, Chalcones, Antimicrobial activity, Ultrasonication.
Abstract
An efficient synthesis of 1,5-Benzothiazepines via Michael addition of corresponding (E)-1-(2-hydroxyphenyl)- 3-(4-(phenylthio)phenyl)prop-2-en-1-one is described under ultrasound irradiation. A series of novel 2-((E)- 2,3-dihydro-2-(4-(phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol derivatives was confirmed on the basis of 1H NMR, Mass, IR spectral data and Elemental analysis. The synthesized compounds were evaluated for their antimicrobial activities. Most of the compounds were found to be comparable potent than the reference standard drugs. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Page
3887 - 3892
Full Text
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