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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 2
BKCSDE 33(2)
February 20, 2012 

 
Title
Radiosynthesis and Biodistribution of an 125I-labeled Resveratrol Derivative
Author
Sung Kew Kim, Woong San Lee, Sang Jin Han, Eun Jung Kim, Mohammed I. El-Gamal, Byoung Soo Kim, Tae Hyun Choi, Chang Woon Choi, In-Hye Ham, Chang-Hyun Oh, Ho-Young Choi, Jung-Hyuck Cho
Keywords
Radiosynthesis, Resveratrol, Iodoresveratrol, Biodistribution, Imaging agent
Abstract
An 125I-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumorbearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.
Page
489 - 491
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