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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 2
BKCSDE 33(2)
February 20, 2012 

 
Title
Preparation of CdSe QDs-carbohydrate Conjugation and its Application for HepG2 Cells Labeling
Author
Mingxing Jiang, Yan Chen, * Guiqing Kai, Ruijun Wang, Huali Cui, Meili Hu
Keywords
CdSe quantum dots, Carbohydrates molecules, HepG2 mannose receptor, Receptor-mediated endocytosis
Abstract
In present study, CdSe quantum dots (QDs) were prepared with a novel but simple, effective and exercisable method. Nine different types of carbohydrate molecules were used to modify CdSe QDs. D-mannose (Man)- coated quantum dots were prepared for labeling human hepatoma (HepG2) cells, because of the high expression of mannose receptor (MR) on HepG2 cells. The uptake characteristics of CdSe QDs-Man were investigated in HepG2 cells. The absorption rate result of MTT assay in 48 h suggested the extremely low cytotoxicity of CdSe QDs-Man. The presence of quantum dots was confirmed with fluorescence microscopy. These results were encouraging regarding the application of QDs molecules for early detection of HepG2 cells.
Page
571 - 574
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