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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 3
BKCSDE 33(3)
March 20, 2012 

 
Title
Synthesis of Biologically Active Chalcones and their Anti-inflammatory Effects
Author
Jae-Ho Jeon, Si-Jun Kim, Cheol Gi Kim, Jin-Kyung Kim, Jong-Gab Jun*
Keywords
Chalcones, Claisen-Schmidt condensation, Anti-inflammatory studies, EDDA, NO production
Abstract
Chalcones have been reported to have various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Due to the limited natural resources, we had to prepare sizable quantities of biologically active chalcones for bio-tests. Therefore, Claisen-Schmidt condensation between substituted acetophenones and corresponding aldehydes enabled us to prepare chalcones for inflammatory studies. Chalcones thus prepared showed significant suppression of nitric oxide (NO) production at 10 μM.
Page
953 - 957
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