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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 5
BKCSDE 33(5)
May 20, 2012 

 
Title
Highly Sensitive Fluorescent Probes for the Quantitative Determination of Singlet Oxygen (1O2)
Author
Syed Rahin Ahmed, Kwangnak Koh, Nam Lyong Kang, Jaebeom Lee*
Keywords
Singlet oxygen, CdTe QDs, LbL method, Fluorescence, Quenching
Abstract
Singlet oxygen (1O2) is an important species for oxidation in biological processes. 1O2 is implicated in the genotoxic effect, and plays an important role in the cell-signaling cascade and in the induction of gene expression. However, the rapid detection of 1O2 in biological environments with sufficient specificity and sensitivity is hampered by its extremely low emission probability. Here, a layer-by-layer (LbL) film of CdTe quantum dots (QDs), polymers, and ascorbate have been designed as a rapid, highly selective, and sensitive fluorescence probe for 1O2 detection. Upon reaction with 1O2, the probe exhibits a strong photoluminescence (PL) response even at trace levels. This remarkable PL change should enable the probe to be used for 1O2 detection in many chemical and biological systems and as an environmental sensor.
Page
1608 - 1612
Full Text
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