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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 5
BKCSDE 33(5)
May 20, 2012 

 
Title
Study of Thiazoline Derivatives for the Design of Optimal Fungicidal Compounds Using Multiple Linear Regression (MLR)
Author
Won Seok Han, Jin Kak Lee, Jun-Seok Lee, Hoh-Gyu Hahn,* Chang No Yoon*
Keywords
Thiazoline derivatives, Magnaporthegrisea, QSAR, Multiple linear regression
Abstract
Rice blast is the most serious disease of rice due to its harmfulness and its world wide distribution. Magnaporthe grisea is the cause of rice blast disease and destroys rice enough to feed several tens of millions of people each year. Fungicides are commonly used to control rice blast. But M. grisea acquires resistance to chemical treatments by genetic mutations. 2-Phenylimino-1,3-thiazolines were proposed as a novel class of fungicides against M. grisea in the previous study. To develop compounds with a higher biological activity, a new series of 2-phenylimino-1,3-thiazolines was synthesized and its fungicidal activity was determined against M. grisea. The QSAR analysis was carried out on a series of 2-phenylimino-1,3-thiazolines. The QSAR results showed the dependence of fungicidal activity on the structural and physicochemical features of 2-phenylimino- 1,3-thiazolines. Our results could be used as guidelines for the study of the mode of action and further design of optimal fungicides.
Page
1703 - 1706
Full Text
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